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경신해지환이 혈중 항비만지표와 독성지표에 미치는 효과에 관한 연구-고지방식이 수컷 비만 쥐를 대상으로

서론

고지방식이 수컷 비만백서에서 경신해지환이 체중 및 사료섭취량에 미치는 영향

정양삼 · 윤기현 · 최승배¹ · 신순식*

Study on Effect of GyeongshinhaeGihwan 1 in Body Weight and Food Intake for High fat Diet Induced Obese Male Rats

Yang Sam Jung, Ki Hyeon Yoon, Seung Bae Choi¹ , Soon Shik Shin*

To investigate the effect of the frequently used anti-obese medicine GyeongshinhaeGihwan 1(GGT1), in food intake, body weight and food efficiency ratio for high fat diet induced obese male rats. Also, to value the diffences between GyeogshinhaeGihwan 1 and FDA approved Sibutramine in anti-obesity effect. High fat diet induced obese male rats were classified into four groups - positive control group, negative control group, GyeongshinhaeGihwan 1 group and Sibutramine group - and their food intake and body weight were observed for eight weeks. Anti-obesity effect was estimated with food efficiency ratio which is calculated by weight increse divided by food intake. The result shown in Fig. 2 suggests that the GyeongshinhaeGihwan 1 group is more effective on food intake control than the Sibutramine group. Average weight variation shows an increase in both positive/negative control group and medication group. Also, the result in Fig. 3 indicates that average food efficiency ratio decreases contrary to the average weight variation. In addition, repeatedly estimated variance analysis on average food efficiency ratio of the GyeongshinhaeGihwan 1 group shows (1) the result corollary to the time of observation of food efficiency ratio was effective under 0.05 variance (P-value : 0.000). The differences between each groups were not shown under 0.05 variance. Compared to the control group, medication groups were visually more effective on food intake control. Although both groups had a tendency of weight increasing, food efficiency ratio considering food intake and weight variation rate showed a decrease. Especially, the medication group variated less than the control group corollary to the point of time, proving the individuals react less sensitive to the medicine. Moreover, there were no differences in the anti-obesity effect between GyeongshinhaeGihwan 1 group and Sibutramine group studied by repeatedly estimating variance analysis(P-value: 0.610). When considering Sibutramine as an anti-obesity medicine approved by FDA, the point of being classifed in the same group proves the effect of GyeongshinhaeGihwan 1 as an anti-obesity medicine.

Key words : GyeongshinhaeGihwan 1(GGT1), Reductil(Sibutramine), high fat diet-induced obese male rats, obesity

서론

경신해지환(GGT1)은 太陰人의 조리폐원탕¹ 가감방으로 임상에서 항비만제로 다수 활용되고 있다. 그럼에도 불구하고 이 경신해지환의 항비만효과에 대한 실험적인 연구는 전무한 실정이다. 비만은 에너지섭취와 에너지소비의 불균형으로 에너지섭취가 에너지소비보다 클때 일어난다. 항비만효과를 입증하는 방법 중의 하나는 체중과 사료섭취량을 측정하여 식이효율을 이용하는 것이다2). 이러한 방법을 이용하는 것은 체중과 사료섭취량 측정이 간단하면서도 중요한 항비만효과를 입증하는 지표가 되기 때문이다.

본 연구에서는 고지방식이 비만수컷 동물모델을 이용하여 경신해지환의 투여가 체중과 사료섭취량에 미치는 영향과 미국 FDA에서 승인된 리덕틸과는 어떤 차별된 효과가 있는지를 검증하고자 하였다.