정양삼한의원

논문 정양삼

> paper > 정양삼

형질전환 비만모델 수컷 hGHTg rats에서 경신해지환(GGT1)이 체중 및 사료섭취량에 미치는 영향

서론

형질전환 비만모델 수컷 hGHTg rats에서 輕身解脂丸 (GGT1)이 체중 및 사료섭취량에 미치는 영향

정양삼#, 최승배¹, 김훈² , 신순식*

The effects GyeongshinhaeGihwan 1 (GGT1) has on the hGHTg (human growth hormone transgenic) obese male rats'body weight and their amount of feed intake

Yang Sam Jung#, Seung Bae Choi¹ , Hoon Kim² , Soon Shik Shin*

ABSTRACT

Objectives: To find out the effects GGT1, an antiobestic drug widely used clinics, has on the amount of feed intake, the amount of change in the body weight and the food efficiency ratio using the data from the hGHTg obese male rats. Also, to evaluate in terms of antiobestic effects, the difference between GGT1 and reductil (sibutramine), which has been approved by the FDA of the United States.

Methods:We measured the change in body weight and the amount of feed intake for 8 weeks by categorizing the hGHTg obese male rats into three groups: the control group, the GGT1 group, and the reductil (RD) group. We also evaluated the antiobestic effect by calculating the food efficiency ratio, which is the increase of bodyweight divided by the amount of feed intake.

Results:In case of body weight, moderate slope of the curve in the graph of GGT1 group could mean that the weight is decreasing as time flows. In case of food efficiency ratio, the p-value was 0.745 in a test for determining if an interaction exists between the group and the point of measurement, meaning that it does not exist; also, the p-value in a test for the effect of level of repetition in food efficiency ratio according to the point of measurement equaled 0.002.

Conclusions:The drug-treated groups had a greater inhibitory effect in feed intake than the control group. The results showed the food efficiency ratio had a tendency to decrease. The GGT1 group in particular was under a greater effect than the RD group.

Key words:GyeongshinhaeGihwan 1(GGT1), Reductil, obesity, food efficiency ratio(FER)

서론

輕身解脂丸 (GyeongshinhaeGihwan 1, GGT1)은 太陰人의 調理肺元湯1)加減方으로 임상에서 항비만제로 다수 활용되고 있다. 그럼에도 불구하고 이 GGT1의 항비만효과에 대한 실험적인 연구는 전무한 실정이다. 에너지섭취와 에너지소비의 불균형으로 에너지섭취가 에너지소비보다 큰 경우에 비만이라고 한다. 항비만효과를 입증하는 방법 중의 하나는 체중과 사료섭취량을 측정하여 식이효율을 이용하는 것이다2). 이러한 방법을 이용하는 것은 체중과 사료섭취량 측정이 간단하면서도 중요한 항비만효과를 입증하는 지표가 되기 때문이다.

본 연구에서는 형질전환 비만모델 수컷 hGHTg (human growth hormone transgenic) 쥐를 이용하여 GGT1의 투여가 비만에 어떤 영향을 미치는 지에 대해서 알아보고, 미국 FDA에서 승인된 리덕틸과는 어떤 차별된 효과가 있는지를 검증하고자 한다.