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GGEx reduces body weight gain adipose tissus mass in hyperphagic and obese Otsuka Long-Evans Tokushima fatty (OLETF)rats

abstract1
GGEx reduces body weight gain and adipose tissue mass in hyperphagic and obese Otsuka Long-Evans Tokushima fatty (OLETF) rats.
Kyungsil Chae1, Young Ho Rho2, Sunhyo Jeong1, Hee Young Lee2, Jinmi Lee1, Yeonhee Hong, Gyeong Chul Kim3, Yang Sam Jung2, Michung Yoon1, and Soon Shik Shin2,*
 
To investigate whether Gyeongshingangjeehwan (GGEx), an herbal medicine widely used in oriental medicine, regulates body weight and adiposity, we measured body weight, adipose tissue mass, feeding efficiency, liver and fat histology, and the expression of adipose specific genes in hyperphagic and obese Otsuka Long-Evans Tokushima fatty (OLETF) rats. Rats treated with GGEx not only significantly decreased body weight gain and adipose tissue mass, but also reduced feeding efficiency and circulating leptin levels compared with controls. Hepatic lipid accumulation was also inhibited by GGEx treatment. Moreover, the administration of GGEx significantly decreased adipocyte size, as evidenced by results for histological analysis. Concomitantly, the expression of adipose marker genes, such as adipocyte fatty acid binding protein and lipoprotein lipase, were substantially decreased by GGEx. Therefore, these results suggest that GGEx effectively suppresses obesity and hyperphagia in OLETF rats. Key Words: GGEx, obesity, hyperphagia, leptin, adipocyte size

Key Words: GGEx, obesity, hyperphagia, leptin, adipocyte size