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GGEx reduces body weight gain adipose tissus mass in hyperphagic and obese Otsuka Long-Evans Tokushima fatty (OLETF)rats

ABSTRACT, INTRODUCTION, PURPOSE
GGEx reduces body weight gain and adipose tissue mass in hyperphagic
and obese Otsuka Long-Evans Tokushima fatty (OLETF) rats.
CHAE Kyungsil1, RHO Young Ho, JEONG Sunhyo1, LEE Hee Young, LEE Jinmi1, HONG Yeonhee1, KIM Gyeong Cheol2, JUNG Yang Sam, YOON Michung1 and SHIN Soon Shik*
ABSTRACT

To investigate whether Gyeongshingangjeehwan (GGEx), an herbal medicine widely used in oriental medicine, regulates body weight and adiposity, we measured body weight, adipose tissue mass, feeding efficiency, liver and fat histology, and the expression of adipose specific genes in hyperphagic and obese Otsuka Long-Evans Tokushima fatty (OLETF) rats. Rats treated with GGEx not only significantly decreased body weight gain and adipose tissue mass, but also reduced feeding efficiency and circulating leptin levels compared with controls. Hepatic lipid accumulation was also inhibited by GGEx treatment. Moreover, the administration of GGEx significantly decreased adipocyte size, as evidenced by results for histological analysis. Concomitantly, the expression of adipose marker genes, such as adipocyte fatty acid binding protein and lipoprotein lipase, were substantially decreased by GGEx. Therefore, these results suggest that GGEx effectively suppresses obesity and hyperphagia in OLETF rats
INTRODUCTION

Obesity and the related disorders of dyslipidemia and diabetes (components of Syndrome X) have become global health epidemics. Over the past decade, the elucidation of key regulators of energy balance and insulin signaling has revolutionized our understanding of fat and sugar metabolism and their intimate link. The three 'lipid-sensing‘ peroxisome proliferator-activated receptors ( PPAR-α, PPAR-δ, PPAR-γ ) exemplify this connection, regulating diverse aspects of lipid and glucose homeostasis, and serving as bona fide herapeutic targets. With molecular underpinnings now in place, new pharmacologic approaches to metabolic disease and new questions are emerging.
PURPOSE

The aim of this study was to investigate whether Gyeongshingangjeehwan(GGEx), an herbral medicine widely used in oriental medicine, regulates body weight gain and adiposity.